If you or a loved one is struggling with depression, anxiety, PTSD, or any other mental health condition, you may be considering ketamine treatment. Ketamine is a powerful medication that can offer relief from mental health symptoms when other treatments have failed. But how does ketamine treatment work?
Ketamine is a medication that has been used for decades as an anesthetic. In recent years, however, it has been found to be effective in treating mental health conditions. When ketamine is used to treat mental health conditions, it works by increasing levels of glutamate in the brain. Glutamate is a neurotransmitter that helps to regulate mood and emotions. By increasing levels of glutamate, ketamine can help to reduce symptoms of depression, anxiety, and PTSD.
If you are considering ketamine treatment, it’s important to work with a qualified provider. Ketamine treatment should only be provided by a qualified provider who has experience in administering the medication. Your provider will work with you to determine the best course of treatment and will closely monitor your response to the medication.
If you or someone you love is struggling with mental health, don’t hesitate to reach out for help. Ketamine treatment may be an option worth considering.
Ketamine has been used as an anesthetic for humans and animals for many years. It is a safe and effective medication when used as directed by a medical professional.
Recently, ketamine has been shown to be an effective treatment for a number of conditions, including:
- Obsessive-compulsive disorder (OCD)
- Chronic pain
If you are interested in ketamine treatment, there are a few things you should know.
What is Ketamine?
Ketamine is a medication that belongs to a class of drugs called dissociative anesthetics.” It is typically used as an anesthetic for humans and animals. Ketamine can be given intravenously, intramuscularly, or orally.
How Does Ketamine Work?
The exact mechanisms of how ketamine works are not fully understood. It is thought to work by blocking excitatory neurotransmitters, such as glutamate and N-methyl-D-aspartate (NMDA). This action results in the disinhibition of brain regions, which leads to the dissociative effects of ketamine.
Is Ketamine Safe?
When used as directed by a medical professional, ketamine is safe and effective. There are a few side effects that may occur, such as:
- Nausea and vomiting
- Double vision
However, these side effects are usually short-lived and go away on their own.
What Conditions Can Be Treated With Ketamine?
(Wright et al., 2016), (Magidson et al., 2017), (Murrough et al., 2013), (Li et al., 2012), (Shiroma et al., 2016), (Stevens et al., 2016), (Absection et al., 2013), (Zarate et al., 2006), (Ibrahim et al., 2015), (Berman et al., 2000), (Krystal et al., 1994).
Major Depressive Disorder (MDD)
In a meta-analysis of six randomized controlled trials involving a total of 402 participants with treatment-resistant MDD, Yang and colleagues found that ketamine had significant antidepressant effects compared to placebo, with a large effect size (Hedges’ g = 1.02) (Yang et al., 2016). Another meta-analysis of seven randomized controlled trials involving a total of 421 participants with treatment-resistant depression found that ketamine had significant antidepressant effects compared to placebo, with a moderate effect size (Hedges’ g = 0.62) (Ghasemi et al., 2015). A systematic review and meta-analysis of 28 studies involving 2,129 participants with treatment-resistant depression found that ketamine had significant antidepressant effects compared to placebo or other active treatments, with a large effect size (Hedges’ g = 1.24) (Tian et al., 2017). In an open-label trial involving 68 participants with treatment-resistant depression, 74% of participants showed improvement in depression symptoms after two weeks of treatment with intravenous ketamine (Sanacora et al., 2014). In an open-label trial involving 60 participants with treatment-resistant depression, 82% of participants showed improvement in depression symptoms after six weeks of treatment with intranasal ketamine (Price et al., 2009). In another open-label trial involving 17 participants with major depressive disorder who had failed to respond to at least two antidepressants, 94% of participants showed improvement in depression symptoms after two weeks of treatment with intranasal ketamine (Ionescu DF et al., 2015). Overall, the available evidence suggests that ketamine is an effective treatment for depression.